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Clinical Pharmacologist - Apogee Therapeutics

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Job Title
Clinical Pharmacologist
Job Location
Job Description


About Apogee Therapeutics
Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.
Apogee Therapeutics, Inc. is a biotechnology company seeking to develop differentiated biologics for the treatment of atopic dermatitis, chronic obstructive pulmonary disease and other inflammatory and immunology indications with high unmet need. Our antibody programs are designed to potentially overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. We seek to reshape the current standard of care for inflammatory and immune diseases because we believe people living with these diseases deserve the best possible treatment, and we refuse to stop at “good enough.”
We are a fast-paced company committed to building an exceptional company culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless. 
If this sounds like you, keep reading!


Role Summary

We are seeking a Clinical Pharmacologist to join the Clinical Development team. In this newly created role you will provide clinical pharmacology expertise to a multidisciplinary team. This individual will be the primary clinical pharmacology lead for programs entering clinical development. This position will work in close collaboration with different functions, including preclinical toxicology, preclinical pharmacokinetics, translational medicine, clinical, operations, and regulatory affairs.

Key Responsibilities

  • Provide Clinical Pharmacology expertise to inform strategy for Apogee’s development compounds using traditional and model informed drug development approaches
  • Represent CP on project teams to provide strategic and scientific expertise
  • Develop and oversee implementation of clinical pharmacology studies from protocol development to final study reporting, in collaboration with cross-functional study team members, including Clinical Operations, Biometrics and Regulatory Affairs, as well as CRO partners
  • Lead the analysis, interpretation, and reporting of clinical PK/PD data; author clinical study reports
  • Oversee PK/PD modeling to support dosing strategies for clinical programs
  • Author clinical pharmacology sections of clinical and regulatory documents, including protocols investigator brochures, and INDs
  • Maintain a current understanding of PK and PD literature and methodology, as well as the scientific literature related to the emerging Apogee pipeline

Ideal Candidate

  • PhD or PharmD with relevant expertise in clinical pharmacology or pharmaceutical science is required
  • 5+ years of direct industry experience in conducting clinical stage drug development
  • Experienced in developing clinical pharmacology plans and authoring relevant sections of clinical and regulatory documents
  • Knowledge and experience in the application of current practices in the areas of clinical pharmacology, pharmacokinetic and pharmacodynamic principles, drug metabolism, bioanalysis, biopharmaceutics
  • Experience in biologic drug development preferred, and/or the immunology and inflammation (I&I) space a plus
  • Fluency in model-informed drug development, with hands-on modeling and simulation experience preferred
  • Experience working with external CROs
  • Proficient in using common PK/PD modeling software (such as Phoenix WinNonlin, Prism, and other similar tools)
  • Ability to work proactively and effectively, with exceptional creative problem-solving skills and self-motivation
  • Ability to work in cross-functional teams within a highly dynamic environment
  • Strong project management skills with high sense of urgency, ability to collaborate and influence effectively cross-functionally
  • Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless
  • Ability and willingness to travel up to 15-20% to company All Hands meetings and development team meetings

The anticipated salary range for candidates for this role will be $190,000 - $200,000. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.


What We Offer
  • A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
  • Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
  • Flexible PTO
  • Two, one-week company-wide shutdowns each year
  • Commitment to growing you professionally and providing access to resources to further your development
  • Apogee offers regular all team, in-person meetings to build relationships and problem solve
E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster.
Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
To review our privacy policy, click here


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Apogee Therapeutics Headquarters Location

San Francisco, CA

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Apogee Therapeutics Company Size

Between 50 - 200 employees

Apogee Therapeutics Founded Year


Apogee Therapeutics Total Amount Raised


Apogee Therapeutics Funding Rounds

View funding details
  • Post Ipo Equity

    $483,000,000 USD

  • IPO


  • Series B

    $149,000,000 USD

  • Series A

    $20,000,000 USD

Apogee Therapeutics' Industries