Chief of Staff - BridgeBio

Who You Are

The Chief of Staff reports directly to the Chief Regulatory Officer (CRO) of BridgeBio. The Office of the CRO (OCRO) spans four pillars—Regulatory Affairs, Portfolio Strategy & Management, R&D Business Operations, and Policy & Advocacy—and this role sits at the center of all of them. The primary objective is to increase the leverage of the CRO, facilitate interactions and information flow across the OCRO and the broader BridgeBio executive leadership team, prepare materials for company leadership and the Board of Directors, take on key cross-functional strategic initiatives, and serve as a strategic thought partner to the CRO.

This role is inherently flexible, taking a central role in whatever is most critical to the OCRO at any given moment. With three NDA submissions before the FDA, a robust pipeline advancing behind them, and a policy and advocacy agenda that is growing in scope and visibility, the OCRO is operating at full throttle. The person in this role will be responsible for organizing, interpreting, and presenting a large volume of complex information—and helping the CRO and OCRO leadership use it to make better, faster decisions. They will help address urgent situations, put out fires, and put in place the processes that allow the OCRO to operate seamlessly across four distinct but deeply interconnected functions.

The Chief of Staff should be:

• Patient-focused
• A clear and structured communicator who distills complexity into concise insights and recommendations—whether the topic is a regulatory strategy, a pipeline tradeoff, an operational challenge, or a policy engagement
• Comfortable operating in ambiguity and able to create clarity where none exists
• Influential without formal authority, able to align senior stakeholders and drive follow-through across the OCRO’s four pillars and beyond
• Highly emotionally intelligent, with a proven ability to handle sensitive information and confidential matters with discretion
• Detail-oriented but never losing sight of enterprise-level priorities
• Biased toward action, with a strong sense of ownership and accountability
• Resilient and adaptable, able to shift gears quickly as priorities evolve across a genuinely wide remit

Responsibilities

• Help define and lead strategic initiatives across OCRO’s four pillars: Regulatory Affairs, Portfolio Strategy & Management, R&D Business Operations, and Policy & Advocacy
• Ensure cross-functional alignment and harmonization of strategy with operational activities across the OCRO and with other functions and affiliates throughout BridgeBio
• Organize, interpret, and synthesize complex inputs into clear insights, recommendations, and decision-ready materials, including succinct presentations for the CRO, OCRO leadership, senior executives, external stakeholders, and Board-level forums
• Manage the operating rhythm of the Office of the CRO by setting agendas, preparing pre-reads, tracking actions, escalating risks, and driving cross-functional follow-through
• Conduct regular reviews of case studies and literature on best practices relevant to the OCRO’s scope
• Manage key meetings with senior leaders across BridgeBio
• Question assumptions and challenge how things are done across BridgeBio in service of the patient mission
• Respond to urgent issues and help coordinate cross-functional efforts
• Perform other strategic analyses and projects as needed
• True expert in the use of AI tools (Claude, ChatGPT), Excel, and PowerPoint

Where You’ll Work

• In-person work is a requirement for 3-4 days per week. The role is based in our Washington DC office with some time spent in offices in Palo Alto, CA and San Francisco, CA
• Domestic and international travel is expected when required

What It Means to Be a BridgeBio Team Member

No matter your role at BridgeBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Passion for delivering life-changing treatment options into the hands of patients
• Familiarity with the drug discovery, development, and regulatory approval process
• Experience working across at least two of the OCRO’s four pillars—regulatory affairs, portfolio strategy, R&D business operations, or policy and advocacy—in a biopharma or life sciences context
• Proven technical and business acumen
• Demonstrated ability to solve problems using a structured, analytical approach
• Ability to handle multiple projects simultaneously
• Comfort working independently and as part of a diverse team
• Exceptional written communication and presentation skills
• Comfort with ambiguity and a self-starter attitude
• Extremely fast learner
• Exquisitely detail-oriented
• Highly empathetic and emotionally intelligent
• 3 to 6+ years of relevant business development / operations / strategy experience in biopharma
• 2 to 3 years of experience in a top-tier professional services firm (e.g., consulting) strongly preferred
• Graduate degree preferred