SECTION I · THE BRIEF
Brief #61798Updated 18 AUG 2026SAN FRANCISCO, CAAshbySV ANGEL
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Antibody Engineering

Chai Discovery creates Chai-1, a multi-modal foundation model designed for predicting molecular structures relevant to drug discovery. The model facilitates the unified prediction of proteins, small molecules, and…

Location
San Francisco, CA
Company size
5–20
Posted
Yesterday
Via
Ashby
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Antibody Engineering · Chai Discovery

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Job title
Antibody Engineering
Job location
San Francisco office
Job description

About Chai Discovery

Chai builds the design suite for molecules. We train frontier models that learn the underlying foundations of biochemical structure and interaction, so scientists can move faster and pursue targets that other methods cannot reach.

AI is reinventing life sciences the same way it reinvented software engineering, and Chai is at the forefront of this shift. Leading pharmaceutical companies like Eli Lilly, Pfizer, and Novartis are rapidly adopting our platform to power their drug discovery programs.

Our mission is to accelerate progress towards new cures and better science, and there are countless interesting problems on the road ahead.

About the role

We are looking for exceptional antibody engineers and computational protein designers to help us evaluate, expand and apply the capabilities of our de novo antibody design models. You'll join an elite team of biologists, computational scientists and AI researchers.

Scientists at Chai are power users and test pilots of our AI platform. We probe the design space for novel targets and formats, validate in silico solutions for function in the lab, and distill empirical rules from the results. We execute experimental programs at scale that guide, train and evaluate next generation models, working closely with our AI research team. We partner with scientists from the world's leading pharma companies to push their discovery programs into new territory. I think you could be a good fit.

This is an opportunity to push the boundaries of applied biology and artificial intelligence. You'll get exposed to a wide array of scientific problems and research methods, far beyond what one encounters working on a single drug program or within a traditional life sciences company.

About you

You have a deep desire to push the limits of what’s possible in therapeutic design, and a restless drive to solve real-world problems and iterate quickly. You are curious, high-agency and incredibly persistent.

  • PhD or equivalent experience in the field—Antibody Engineering, Computational Biology, Protein Sciences.

  • Hands-on experience with design and characterization of antibody-based biologics. Proficient in molecular-biology workflows, binding and developability assays, inspecting structures in PyMOL or similar tools.

  • Track record of strong communication, collaboration and execution.

We offer

The opportunity to work at the vanguard of AI research and frontier biology, with world-class people, on a mission that matters. We protect & promote a culture of high velocity and ownership. We compensate our team accordingly.

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Where this role is based

San Francisco, CA

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Chai Discovery headquarters

San Francisco, CA

Company size

520 employees

Founded

2024

Total raised

$231,000,000

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Funding rounds

  • Series B$130M
  • Non Equity Assistance$1M
  • Series A$70M
  • Seed$30M