Senior Operational Technology Engineer

Cellares is revolutionizing cell therapy manufacturing. Cellares is developing a one-of-a-kind solution, The Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are…

Location: South San Francisco, CA
Company size: 50–200
Posted: 2mo ago
Via: Lever

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Senior Operational Technology Engineer - Cellares

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Job Title: Senior Operational Technology Engineer
Job Location: South San Francisco, CA
Job Listing URL: https://jobs.lever.co/cellares/cfd5a890-aab8-4e20-8d67-e1b7d0a8f736
Job Description: We are seeking a hands-on Senior Operational Technology Engineer to lead and support IT/OT operations in a global cell therapy manufacturing lab environment.

This role is responsible for end-to-end OT infrastructure, including network and security on proprietary equipment, while ensuring secure access management, compliant change control, and 24x7 operations. The ideal candidate will combine deep technical expertise with strong leadership to drive system reliability, scalability, and regulatory compliance across multiple sites.

Candidates should enjoy working in a fast-paced, mission-driven environment, and be prepared to tackle a broad selection of challenges as the company grows.

Responsibilities
Manage and deliver OT systems and technology for the company’s industrial and cell manufacturing environments

Own and maintain a robust OT roadmap, including project objectives, prioritization, and implementation plans

Ensure OT production environments adhere to security best practices and comply with relevant regulations

Provide hands-on technical support and troubleshooting for production-related OT/IT issues, ensuring minimal disruption to 24x7 operations

Implement and monitor OT production systems to guarantee 24x7 uptime and reliability, including network, server, biotech manufacturing lab, and proprietary equipment

Develop and deliver training programs for new OT staff relating to production environment

Contribute to creating, maintaining SOPs, Policies, and Process

Lead and support GMP-related activities, including change control, system validation, qualification (IQ/OQ/PQ), and audit readiness

Own OT access management processes, including user provisioning, role-based access control, and periodic access reviews to ensure compliance with GxP, data integrity, and cybersecurity requirements

Ensure compliance with industry regulations, standards, and best practices related to OT and data security

Provide backup support to Corporate IT as needed to ensure continuity of enterprise IT services
Requirements
Bachelor's Degree in related field or proper training

7+ years of relevant experience

Proven experience in IT management with a manufacturing or industrial setting, with a strong focus on 24x7 operational support

Experience with monitoring, server management, and cybersecurity best practices

Experience with Fortigate firewalls, Hirschmann industrial switches, lab and warehouse equipment

Experience with various applications such as Nutanix Prism, SharePoint, and JIRA

Experience working in a biotech regulated environment

Knowledge of and experience with current Good Manufacturing Practices (cGMP) required

Ability to independently prioritize work and deliver results effectively in a fast-paced environment.

Ability to be a strong problem-solving skills and the ability to work under pressure

Requires availability for on-call support and extended hours during critical system issues to maintain 24x7 operations

Self-awareness, integrity, authenticity, and a growth/entrepreneurial mindset