The Opportunity:

Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Research organization as a Scientist I, Medicinal Chemistry.  This individual contributor role will work as a key member of an integrated, multidisciplinary drug discovery team making significant contributions toward the discovery of important new drug candidates.

Responsibilities:

• Design and synthesis of biologically active compounds to support SAR:

  • Analysis of biological data.

  • SBDD based design of analogs.

  • Planning and execution of the synthetic routes, synthesis purification of final targets.

• Recommend alternative synthetic routes, research new methods and techniques, and proactively seek out others to identify solutions to challenges.

• Present research findings to the Medicinal Chemistry team and management.

• Partner in the scientific activities of other outstanding medical chemists and cross functional team members and create an environment where all ideas are shared.

• Collaboration with external teams, CROs (contract research organizations).

Required Skills, Experience and Education:

• D. with a background in synthetic organic chemistry and 0-3 years of postdoctoral or relevant pharma/biotech industry experience.

• Strong understanding of synthetic organic and medicinal chemistry.

• Experience with NMR, HPLC, and Mass Spectrometry techniques.

• Familiar with modern synthetic, organic chemistry techniques and instrumentation.

• Well versed in synthetic methodologies and can independently design and execute synthetic procedures.

• Strong written and verbal communication skills to work with interdepartmental teams.

• Ability to multi-task, be efficient and well-organized, and work collaboratively as a team player with high energy in a dynamic and fast-paced environment.

Preferred Skills:

• Demonstrated experience in the total synthesis of complex molecules, including multistep route design, synthetic problem-solving, and stereochemical control.

• Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.

• Experience in oncology drug discovery research.

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