Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history.
We are seeking an experienced, hands-on Protein Sciences leader to oversee protein science activities conducted internally and through external CRO partners. This is an opportunity to join Alector at a critical inflection point, lead and develop a small internal team, and build new capabilities supporting our growing focus on antibody–oligonucleotide conjugate therapeutics. This individual will serve as a cross-functional scientific connector and directly manage members of the Protein Sciences team. The ideal candidate combines strong people leadership and external-partner oversight with a willingness to work in the laboratory to train colleagues, introduce new techniques, and troubleshoot complex technical challenges.
Key Goals & Accountabilities
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Build capabilities for emerging modalities. Establish and evolve protein purification, conjugation, and analytical capabilities to advance antibody–oligonucleotide conjugates and other emerging program needs.
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Develop the team and scale our impact. Manage, mentor, and develop a small Protein Sciences team while providing hands-on technical guidance and effectively leveraging external CRO partners to meet program priorities and timelines.
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Accelerate programs from research toward development. Partner across discovery, platform, development, CMC, and other teams to advance lead candidates, ensuring production and analytical strategies address developability, process viability, and manufacturing considerations.
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Innovate how we work. Integrate new technologies, including AI and large language models, into Protein Sciences workflows to accelerate programs, generate insights, and use resources more effectively.
Required Qualifications
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PhD in biochemistry, molecular biology, biophysics, protein sciences, or a related scientific discipline with 8+ years of relevant biotechnology or pharmaceutical industry experience, or an equivalent combination of MS/MSc with 10+ years of relevant industry experience.
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Significant biotechnology or pharmaceutical industry experience in protein sciences, therapeutic antibodies, or related biologic modalities, including experience leading and developing scientific staff.
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Broad scientific expertise across protein production, purification, characterization, and analytical methods, with hands-on experience using FPLC/AKTA and familiarity with HPLC, mass spectrometry, or related analytical platforms.
Preferred Qualifications
