Companies by HQ LocationTech Companies and Startups Headquartered in Cambridge

Sora Fuel makes jet fuel from just air, water, and renewable energy. Sora Fuel combine carbon capture and utilization into a single process, dramatically reducing the amount of energy required to produce SAF, enabling a truly affordable, carbon-negative drop-in solution.

A machine learning and artificial intelligence platform company.

CuspAI is a revolutionary AI startup that is developing a platform for next-generation materials to address global sustainability and renewable energy concerns. CuspAI uses cutting-edge generative AI, deep learning, and molecular simulation to accelerate the material design process. Their platform works similarly to a search engine for materials, allowing users to request certain properties for new materials on demand.

VULCAN ELEMENTS is changing the way to electrify aerospace, defense, and auto with decarbonization.

Osmo gives computers a sense of smell that improves the health & wellbeing of human life.

MacroCycle is developing a technology to curb the usage of fossil fuel derived plastic through a circular, sustainable and zero-carbon plastic upcycling process. The company's proprietary process based on the synthesis of cyclic macromolecules enables us to produce virgin-grade recycled PET from plastic waste at lower energy use than traditional processes.

Synthpop is a company that develops AI-driven solutions to streamline healthcare workflows and improve patient care. The company's platform leverages advanced technologies to automate data entry, insurance verification, and other administrative tasks, freeing up healthcare professionals to focus on core clinical responsibilities.

Pi Health is a provider of platforms to assist oncology-related clinical trials with identifying sites and helping sponsors manage sites

Koya AI helps data aggregators such as marketplaces and procurement platforms to manage catalog data seamlessly. Instead of spending days manually chasing down, standardizing, and enriching product data, marketplaces can rely on Koya’s data-as-a-service offering. Bad data is the next frontier in ecommerce. Crucial services such as search and discovery, bringing new products live, and recommendations depend on product data quality. This data varies widely across providers and changes frequently, creating tremendous complexity. Today, most marketplaces and data aggregators manage these workflows manually, which is slow, inaccurate, and cumbersome. Seller listings are delayed, users have a poor on-site experience, and the marketplace sees lower conversion rates. Koya helps our clients obtain, normalize, and continually update product data with the power of Machine Learning.

Our mission is to help you reclaim your health from mold. Learn more at www.moldco.com

Developer of the world's first cloud-native operating system, DBOS, and the DBOS Cloud transactional serverless computing platform. A simpler, more secure way to build fault-tolerant cloud applications. Based on 3 years of joint MIT-Stanford research, led by DBOS co-founder and Turing Award laureate, Mike Stonebraker.

Liquid AI is a developer of AI applications that help improve human experience. It focuses on researching and developing tools that use artificial intelligence to improve creative workflows and help clients manage their workflow efficiently.

Symbionics is a brain-computer interface company that focuses on the development of interface devices to integrate humans and machines.

Sesame Sustainability is a SAAS company that offers industrial decarbonization platform for modeling, optimization, and analysis.

Marveri is a legal AI startup out of MIT & Harvard. We’re focused on revolutionizing the legal industry and backed by top-tier investors. We are currently in stealth.

Pascal is an early stage Boston-based clean technology company, commercializing solid refrigerant heat pumps and air conditioners. The HVAC sector currently accounts for 30% of total global energy usage while also directly emitting 1.5 GTon CO2 eq. of greenhouse gas refrigerants to the atmosphere. Pascal’s solid refrigerants undergo solid-solid phase transitions and are able to operate in the same pressure and temperature ranges as standard gas refrigerants. Pascal's solid refrigerant based systems eliminate the direct emission of refrigerants to the atmosphere while achieving higher energy efficiency than vapor compression systems.

Omnipulse Biosciences offers single injection quantities suitable for clinical trials and commercial distribution to low-income countries

Tailbox is an MIT-backed startup bringing locations to life through generative AI powered stories. Our location-based social platform for explorers focuses on uncovering hidden gems and unique narratives in every city through immersive storytelling and personalized experiences. We are transforming the way people interact with their surroundings by bringing an entirely new and enriching perspective to traveling and exploration.

Passkey Therapeutics is pioneering a new class of medicines, Synergistic Multifunctional Therapeutics (SMThs). It is designed to address complex diseases by targeting rare combinations of proteins that work together.

Cartwheel offers mental health support to students in order to help schools regain balance in the midst of the student mental health crisis. It works hand in hand to empower school staff, reduce family stress, and improve all students' mental health outcomes. Its FERPA- and HIPAA-compliant program i... Read more

Basys.ai automates the process of prior authorization and utilization management to improve costs and timeliness for health plans/payers using an AI-based platform. The proprietary platform automates the process of encoding/digitizing the payer policies using machine learning, thus reducing the piloting timeline by up to 9 months.

Via Scientific to help scientists and bioinformaticians generate novel science that improves the world. It was founded in 2022.

Entro is a revolutionary cyber security platform that provides protection for secrets and programmatic access to cloud services and data. They assist in accelerating business growth and success by building a safe cloud environment.

Lithios is a technology company that uses electrochemistry for advanced lithium extraction from tough mixtures.

Suno is a music start-up that enables anyone to make the songs they want. The company aims to help people rediscover the joy of play and exploration.

StataDX is building the world's first point-of-care diagnostics platform for Neurology.

Istari makes digital engineering ecosystems a reality where all technologies are created digitally, free from real-world costs, schedules, and environmental impacts.

FORAY bioscience is a biotechnology company that uses biomanufacturing techniques to produce wood products.

Wecover Platforms creates AI-powered PaaS for Property and Casualty Insurance Industry

ProFound Therapeutics is creating profound impacts on the understanding of biology and disease and the ability to create therapeutics.

Pramana, Inc is a new health technology company from nference that enables digital transformation for next-generation pathology at medical centers and pathology labs. Pramana offers a first-in-class Digital Pathology as a Service (DPaaS) solution by providing a turnkey service offering with cutting-edge whole slide imaging systems and a scalable software platform for clinical workflows. Pramana is a gateway for pathologists to utilize AI-enabled decision support leveraging applications developed by nference and other healthcare technology companies. The Path to Pramana: Pramana is a result of nference’s venture into digital pathology which began with the acquisition of Spectral Insights in April 2020. By successfully integrating the strong hardware capabilities of Spectral Insights and robust software expertise of nference, Pramana’s Digital Pathology as a Service (DPaaS)* has been developed to serve pathologists and improve patient care worldwide.

With Stack AI, any organization can build and deploy custom AI Assistants in minutes. Our no-code interface allows teams to leverage AI for searching through knowledge bases, automating workflows, and building chatbots. Hundreds of companies use Stack AI to build custom knowledge-base assistants, automate customer support, scrape data from the internet, and analyze large volumes of documents.

Nvelop Therapeutics is a biotechnology company that provides gene editing technology services for unmet major disease needs.

DEM Bio is pioneering the next generation of immunotherapeutics that unleash macrophages and immune phagocytes to eliminate tumors by targeting ‘Don’t eat me’ (DEM) and ‘Eat me’ (EM) signals on cancer cells and macrophages. Founded by Longwood Fund and is supported by a syndicate of biotech investors and headquartered in Boston, MA.

We develop scalable quantum computers to tackle the world’s hardest computational challenges. Join us: https://jobs.polymer.co/atlantic-quantum.

Datalign Advisory is a financial advisory firm that connects clients with a network of financial advisers.

Mantel is developing the first molten-salt based carbon capture technology. Our molten borates are designed to operate at the high temperatures found inside boilers, kilns, and furnaces – enabling highly efficient carbon capture that has not been possible until now. Carbon capture can be applied across industry to reduce emissions - and even achieve net-negative emissions. By solving for efficiency Mantel can reduce energy losses by more than 60% and cut costs in half, unlocking carbon capture’s role in reaching global net zero.

Digital twins are revolutionizing industries from aerospace to agriculture. Istari makes them simple and more secure, unlocking models and simulations for better products - better everything. A faster, cheaper, greener digital future awaits. With Istari, simple and secure collaboration finally come... Read more

Wild Microbes is a next-generation microbial platform that makes everything from plastics to proteins. They develop new microbial strains, making scaling sustainable products faster and cheaper than ever.

NuMind is a manufacturing company currently based in Cambridge, Massachusetts, United States. It has been founded in 2022 by Etienne Bernard and Samuel Bernard.

Sleepagotchi rewards users with a digital collectible for sticking to a consistent sleep schedule that they set for themselves in order to promote healthy sleeping habits.

Orbital Therapeutics aims to enhance global health by unleashing the full potential of RNA-based medicines to treat human disease in ways that were not previously possible.

Diagonal Therapeutics is a biotechnology startup that is pioneering a novel technique to finding and producing agonist antibodies. Diagonal Therapeutics platform combines novel computational and experimental methodologies to solve the traditional obstacles associated with agonist antibody drug development.

Founded by Flagship Pioneering, Empress re-imagines the process of small molecule drug discovery. Our bioplatform harnesses the power of evolution, human molecular and genetic data, and artificial intelligence to focus on endogenous sources of inherently drug-like small molecules as a uniquely quali... Read more

Montai is harnessing nature's power through digital technology to treat and prevent chronic disease, hence improving health outcomes for as many people as possible. To address this crucial global concern, the business is pioneering cutting-edge technology to develop AnthromoleculeTM medications, whi... Read more

Foundation Alloy leverage advanced materials technology to design novel alloys optimized for additive manufacturing.

Yard Stick measures soil carbon. Scientists and farmers alike know that climate-friendly agricultural practices have the potential to remove atmospheric CO2 at gigaton/year scale. When these practices are adopted, more carbon is stored in soils, improving soil health and fighting climate change. But significant measurement challenges have held soil carbon efforts back - until now. By reducing the cost of soil carbon measurement by 90%+, Yard Stick will dramatically expand the opportunities for evidence-based regenerative practices to simultaneously improve ecosystem health, increase farmer income, and combat climate change.

Beta Finance is a permissionless money market protocol for lending, borrowing, and short-selling crypto assets. It aims to offset crypto volatility and bring market stability. Its one-click solution enables traders without technical know-how to manage and update their short positions on any token with all relevant token information directly available on the interface to guide their decision.

Photys Therapeutics’ proprietary bifunctional small molecules platform unlocks fine-tuned control of protein post-translational modifications, going beyond degradation to restore protein function, repair signaling, and amplify endogenous disease-fighting mechanisms. Photys was co-founded by the Broad Institute’s leading bifunctional chemist, Amit Choudhary, and the Longwood Fund, alongside a scientific advisory board comprised of distinguished scientists and drug developers – MIT’s Angela Koehler, Salk’s Tony Hunter, Berkeley’s Dan Nomura, MPM’s Wendy Young, and Dana Farber’s Eric Fischer.

OpenEvidence Information overload is a common problem in many high-value domains. It's a huge challenge in medicine. With such a rate of change, it is practically impossible for the world's physicians, medical scientists, and healthcare professionals to keep up with and comprehend all of the most recent research literature and clinical evidence pertinent to their work. Our contribution to the global effort to tame the medical information firehose is OpenEvidence: Artificial intelligence is applied in our strategy to aggregate, synthesize, and visualize clinical evidence in intelligible, clinically valuable formats that can be exploited.

Abata Therapeutics, a company focused on translating the biology of regulatory T cells (Tregs) into transformational medicines for patients living with progressive multiple sclerosis (MS) and other severe autoimmune and inflammatory diseases.

hC Bioscience is an innovator and pioneer of protein editing using context agnostic engineered tRNA. Their First in Class approach for protein editing advances beyond genome editing to direct modification of the proteome.

Seeded by Atlas Venture and The Column Group and in stealth-mode, Judo Bio is pioneering development of a new class of precision therapeutics targeting specific cell populations, a platform that will ultimately have the potential to address significant unmet medical need in genetic diseases and beyond. Leveraging our innovative receptor targeting approach, we are working to build a pipeline that will benefit patients impacted by both common and rare disease. Enabled by a network of high caliber experts and internal talent, we are thoughtfully building a team of passionate, innovative, and energetic scientific champions to discover and develop therapeutics that have the potential to change the lives of patients and families.

Anumana is an AI-driven company that develops ECG algorithms enabling early disease diagnosis and intervention.

Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets for transcription factor regulation to address mutations that cause disease. Our drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.

Mirai Bio has developed an open platform powered by AI to address the main drawbacks and manufacturing to develop the future of genetic medicine.

We are reinventing a future Internet. Private. Personal. Relevant. Powered by extraordinary technology. No cookies harmed in the process.

Trove Health is a company that provides a platform for patients, providers, and life sciences to access patient data.

Apollon offers more simple diagnostic techniques. It can detect inflammatory substances in a single blood sample and measure blood sugar without collecting blood. All of this is possible because light can unlock the signal of chemical bonds in molecules without hurting even the most fragile analytes. To achieve such an ambitious goal, we've gathered a proven team and collaborated with world-class experts from Asan Medical Center, MIT and Harvard Medical School. It is important to note that Apollon is not limited to a single type of biomedical technology. We believe that by keeping an open mind about what is possible, we will be able to achieve the best results for patients all around the world. Apollon was founded in 2021 by an experienced healthcare entrepreneur, as well as medical engineers and clinicians. We have R&D and business operations in Seoul and the Greater Boston area (in process), and we are looking for experts who share our vision for the future. The essence of digital healthcare is to minimize travel so that you can receive clinical help whenever and wherever you need it. Diagnostics that require additional processing will have no place in the future.

Tutor Intelligence is on a mission to bring robots to places they've never been before. We have made it cheap and easy for businesses of all sizes to hire robots as drop-in solutions for picking, placing, pal/depal, material handling, sorting, kitting, inspection, and more.

Osmoses engages in decarbonizing gas separations to eliminate one gigaton of carbon emissions per year.

Metaphore Biotechnologies use biomimicry and machine learning to unveil the revolutionary medicinal potential of functional molecular mimics. The MIMiCTM platform, developed by the business, is a computationally driven bio platform for developing novel therapies in which function, specificity, and selectivity may be optimized. Metaphore is dedicated to uncovering previously inaccessible pharmacological targets and achieving breakthroughs that exceed today's medications for maximum patient effect.

FYTO is a technology company that develops systems that grow high quality crops using much less resources.

Garuda Therapeutics is developing off-the-shelf hematopoietic stem cell (HSC) therapies to treat a broad range of severe and life-threatening diseases.

Sunbird Bio is a leader in protein-based diagnostic tests, becoming the first company to overcome the challenge of accurately detecting and differentiating the specific proteins that aggregate, and therefore signal the presence of Alzheimer’s disease, with a simple blood draw. We are addressing the tremendous, growing need for more reliable and sensitive diagnostic tests to accelerate drug development and enhance patient care. Our pipeline of innovative, non-invasive technologies, such as our APEX technology, will empower researchers and clinicians with unparalleled insights not available from current tests.

Fizz is building a debit card that helps college students in the U.S. started building out their credit without having to learn lessons about overzealous credit use the hard way.

Prologue Medicines creates transformative medicines by systematically discovering and evaluating viral proteins and their unique features.

Thousands of collectors use evaluate.market to analyze NFTs. We are a remote, venture-backed company that is changing how people buy, sell, and analyze digital collectibles. Connect with us on Twitter and join our Discord to learn more.

ReNAgade Therapeutics focuses on the boundless potential of RNA therapeutics to treat disease. RNA delivery systems with a comprehensive RNA platform that allows for an all-RNA system for coding, editing, and gene insertion to produce new medications.

Fourth Power is an energy storage startup that uses thermal batteries. Through utility-scale thermal storage, the technique transforms renewable energy into an on-demand energy source.

Gesund.ai orchestrates the AI as-a-Medical Device lifecycle, providing privacy-centered access to diverse yet standardized medical data sources, and a unique analytical toolbox that fosters clinical validation, regulatory clearance and effective marketing.

Stack is a B2B SaaS computer vision information system company that aims to rethink the way warehouses are managed across the United States.

Conduit enables financial platforms to connect their customers with higher earning crypto products using one API for DeFi

Heyday Health offers primary care for adults providing in-home and video visits, clinical team, and continuous accessibility.

Axoft’s bioinspired, scalable implant promotes long-term communication with the nervous system - transforming clinical outcomes, individual health, and the human experience.

Skylark Bio is a biotechnology company that develops gene therapies to treat hearing losses. The company was founded in 2021 and is based in Cambridge, Massachusetts, United States.

SanaHeal provider of a bioadhesive tape designed to bind to tissues or organs

Centessa Pharmaceuticals is a next-generation biopharmaceutical company that aims to reshape the traditional drug development process. The company applies an asset-centric R&D model at scale to advance a portfolio of highly validated programs led by industry-leading teams. Each program is developed by a Centessa Subsidiary and supported by a centralized infrastructure and the Centessa management team.

Robigo is a biopesticide engineering the plant microbiome to reduce disease in crops.

Matchpoint is a biotechnology company harnessing the power of covalency to discover precision covalent medicines to transform the treatment of immune diseases and other serious illnesses. The company's proprietary Advanced Covalent Exploration (ACE) platform integrates advanced chemoproteomics, machine learning, and covalent chemistry libraryevolution. Matchpoint has an emerging pipeline of novel covalent medicines, initially focused on immunology.

Themis AI, a spinoff from CSAIL MIT, was founded by MIT alumni and professors to empower the world to create, advance, and deploy trustworthy AI. Themis' technology enables trustworthy AI in high risk scenarios, rare events and anywhere imbalances and biases can be found within training data. Their technology is delivered via an end-to-end Risk Aware AI Workflow. Their product enables trust, explainability, robustness, and fairness in AI from data curation to model deployment and is designed for data scientists and machine learning engineers. Themis has received great traction from companies that are working on high-risk use cases and algorithms making decisions that affect humans. The former includes use cases where model failures can be catastrophic (autonomous vehicle, autonomous airplane, defense, etc.), and the latter includes decisions such as loan qualification, hiring, insurance, etc.

K36 Therapeutics mission to translate epigenetic modulation of oncogenic pathways into first-in-class small molecule therapies.

Dianthus is the world’s only AI-first E-commerce company – built from the ground up to help small to medium E-commerce brands.

Atavistik Bio is a pre-clinical biotechnology company pioneering the identification of metabolite-protein interactions that have the potential to lead to the discovery and development of first-in-class drug candidates powered by distinct allosteric control mechanisms.

Crossbow Therapeutics is a seed-stage, stealth-mode oncology startup company. The company develops antibody engineering for intracellular cancer targets.

Kano Therapeutics enables safe, effective, and flexible correction of gene-length stretches of DNA through a new class of biomaterials.

Convergent Therapeutics is a clinical-stage biotechnology company exploring the full potential of dual-targeted combination strategies to treat cancer. Convergent has developed a therapeutic platform that is capable of targeting validated and novel cancer antigens. Building on breakthrough research developed by Dr. Neil Bander at Weill Cornell Medicine, Convergent has demonstrated that dual targeting of surface cancer molecules like Prostate-Specific Membrane Antigen (PSMA) improves antitumor efficacy. By leveraging targeting agents with different bio-distributions, such as monoclonal antibodies and ligands, supra-additive therapeutic doses are delivered to tumor cells without additive toxicity to the patient.

Ketryx is an information technology company that features software development tools built for developers, by developers.

ElevateBio is an operator of a portfolio of cell and gene therapy companies intended to develop, manufacture, and commercialize life-transforming medicines. The company creates a portfolio through partnerships with the world's innovative scientists and inventors as well as it created a centralized facility that integrates all the elements that translate cell and gene therapy R&D into commercially viable therapies quickly and efficiently, enabling patients to get medical products to treat severe diseases. Vikas Sinha, Mitchell Finer, and David Hallal co-founded ElevateBio in Cambridge, Massachusetts in 2017.

As schools and businesses return to work, they will be met with a number of new challenges: keeping students and employees safe, tracking outbreaks, and communicating to the public that they are taking responsible precautions. CoVerified provides a professional suite of user-friendly tools for schools and employers including a symptom & screening app, track & trace for co-worker contacts, test result verification, and dynamic return-to-activity monitoring. CoVerified is the most comprehensive solution on the market, and we’re here to be a personal guide on the journey back to normal.

AavantiBio is a biopharmaceutical company that provides gene transfer and gene editing therapies to treat genetic diseases.

Bicara Therapeutics, a wholly-owned subsidiary of Biocon based in Boston, U.S., is developing a pipeline of bifunctional antibodies that exploit the recent advances in immuno-oncology. Bicara enables access to the thriving innovation ecosystem in the U.S. which accelerates the development of cutting-edge therapies for cancer. Synergies between the scientific teams in Boston and Bengaluru will pioneer rapid and cost-effective breakthrough innovation.

Woho enables a new way to build, assembling a team, network, and system to construct from low to high-rise structures with unprecedented quality, precision, and efficiency. The company was founded in 2020 and based in Cambridge, Massachusetts.

Tagomics transform disease diagnosis through comprehensive multitopic profiling.

Common Sense Machines is building artificial intelligence that learns to translate the world into a 3D simulation. Our platform, Real-to-Sim-to-Real, leverages the flexibility of human-like learning and the speed and precision of machines to enable one-shot 3D perception and manipulation of everyday objects.

Fluent Metal is developing production-grade liquid metal printing technology for more functional, sustainable, and economical metal parts. Our innovative approach allows for high scalability and process tunability, making high-quality metal AM more attainable than ever. Our mission is to revolutionize metal additive manufacturing by offering cost-effective and reliable metal 3D printing technology, fostering innovation across industries.

Ceretype has pioneered the integration of fMRI into therapeutic applications in neuropsychiatry. Our uniquely scalable platform makes targeted biomarkers accessible, delivering actionable insights for our pharma/biotech partners. Our decades of expertise across neuromedicine, brain imaging, and industry processes enables innovations that will ultimately transform patient care.

Verve's mission is to improve the limits of worker safety and well-being by pioneering the integration of robotics into functional apparel. They commercialize a lightweight, one-size fits most wearable that powers and protects workers all day long, so they can have safer work days and more restful n... Read more

SalioGen Therapeutics advances in curative genetic therapies using its Exact DNA Integration Technology (EDIT) platform, a mammal-derived genome engineering technology. It is focused on providing durable, safe, and affordable non-viral gene therapies to more patients with inherited diseases. Looking ahead, SalioGen will also explore the EDIT platform’s capabilities to streamline cell therapy, cell engineering, and biologics manufacturing to help an even broader population of patients in need.

NextPoint Therapeutics develops medications to expand the benefit of immunotherapies to cancer patients. The company offers immunotherapies for a validated checkpoint axis that is independent of PD-1/L1 and modulates both adaptive and innate immune systems to find and destroy cancer cells.