COMPANY PROFILE · UPDATED 01 AUG 2026

Spyre Therapeutics

Spyre Therapeutics combines best-in-class antibody engineering, rational therapeutic combinations, and precision immunology approaches to maximize efficacy, safety, and convenience of treatments for inflammatory bowel disease.

San Francisco, CA

spyre.com ↗

Healthcare & Biotech Biotech & Drug Discovery Medical Organizations Health Care Companies Public Biotechnology Companies

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Founded: 2023
Headcount: 83
Open roles: 6
Last raised: Post Ipo Equity

LOCATIONS

Where they work

Spyre Therapeutics offices

San Francisco, CA

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FUNDING

Capital raised

Total raised

$1,324,000,000

Investors

Funding rounds

Post Ipo Equity
$403MApr 14, 2026
Post Ipo Equity
$275MOct 12, 2025
Post Ipo Equity
$200MNov 17, 2024
Post Ipo Equity
Affinity Asset Advisors, Great Point Capital, Boxer Capital, Commodore Capital, Deep Track Capital, Woodline Partners, Access Industries, Cormorant Asset Management, Venrock Healthcare Capital Partners, RTW Investments, Perceptive Advisors, Fairmount Funds Management, Braidwell, Polar Capital Holdings
$180MDec 6, 2023
Post Ipo Equity
$210MJun 21, 2023
IPO
UndisclosedJan 1, 2016
Series B
Lilly Ventures, Novartis Venture Fund, New Ground Ventures, UT Horizon Fund, RA Capital Management, Cowen Healthcare Investments, Venrock, OrbiMed Advisors, Ally Bridge Group, Jennison Associates, Rock Springs Capital
$44MMar 22, 2015
Series A
Lilly Ventures, KBI Biopharma, Novartis Venture Fund, UT Horizon Fund
$12MFeb 5, 2014

Funding data via Diffbot, SEC EDGAR filings and company announcements — a round from a filing or announcement links to it

TECH STACK

How Spyre Therapeutics builds

OPEN ROLES

Hiring at Spyre Therapeutics

View all 6 open roles →

LEADERSHIP

Founders & key people

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