Senior Director, Clinical Pharmacology - REVOLUTION MedicinesView Company Profile
- Job Title
- Senior Director, Clinical Pharmacology
- Job Location
- Redwood City, California, United States
- Job Listing URL
- Job Description
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
We are seeking a highly motivated and energetic individual with a relevant scientific background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.
As a key member of Clinical Pharmacology, you will:
Provide strategic insight and technical leadership within the clinical pharmacology function.
Lead the design and execution of an integrated clinical pharmacology and modeling and simulation strategy to guide the clinical development plan.
Apply state-of-the-art quantitative modeling, including translational PK/PD, population PK, exposure-response analyses, and system pharmacology, to integrate nonclinical data and clinical data to guide dose/schedule optimization and recommended phase 2 dose and schedule (RP2Ds) selection.
Author and provide technical input for regulatory documents and submissions related to all aspects of clinical pharmacology (including the protocol, IB, briefing package, etc) and responses to regulatory questions.
Engage and work with consultants and/or CROs on clinical pharmacology activities to complement in-house knowledge/expertise and capacities.
Represent the clinical pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.
Required Experience, Skills, and Education:
A Ph.D. or Pharm.D. with 10+ years of clinical pharmacology or relevant industry experience.
Prior experience with small molecule in oncology drug development is preferred.
Demonstrated experience and track record in designing and executing dedicated clinical pharmacology studies and clinical pharmacology components of clinical studies.
Track record of applying modeling and simulation methodologies to inform and accelerate drug development.
Well-informed in current and emerging scientific standards of regulatory requirements and expectations.
Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.
Strong interpersonal skills, and ability to influence development projects and management teams.
A critical thinker and passionate team player with high energy who thrives in a dynamic and fast-paced environment.
Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.
The expected salary range for this role is $240,000 to $294,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
REVOLUTION Medicines Headquarters Location
Redwood City, CA
REVOLUTION Medicines Company Size
Between 100 - 500 employees
REVOLUTION Medicines Founded Year
REVOLUTION Medicines Total Amount Raised
REVOLUTION Medicines Funding RoundsView funding details
Post Ipo Equity
Post Ipo Equity