Scientist II, Neuroscience, Translational Medicine - Insitro

The Opportunity

The heart of insitro’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and small molecule discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented translational scientists who want to make a difference to this important problem. The Scientist II, Translational Medicine  will be responsible for leading and/or executing in vivo studies focused on characterizing the efficacy and safety of novel therapeutics/drugs to advance insitro’s development pipeline. Specifically, the candidate will work in a cross-functional, multi-disciplinary environment to establish proof-of-concept, pharmacokinetic and pharmacodynamic relationships, and safety/toxicology for therapeutics/drugs in relevant animal models with a focus on neurological disease. A successful candidate will be flexible, collaborative, innovative, and rigorous and will thrive in a dynamic, exciting, and high-impact environment.      

In broader context, you will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

 Primary Responsibilities 

• Evaluation and prioritization of relevant in vivo models to assess predictive validity for neurological diseases and disorders. 
• Evaluation and prioritization of different therapeutic modalities, routes of administration, and mechanisms of action for in vivo models of neurological diseases and disorders.  
• Evaluation and prioritization of different endpoints/biomarkers that translate from in vivo studies to clinical trials.
• Design, execution, interpretation, and reporting of in vivo studies covering proof-of-concept, pharmacokinetics, pharmacodynamics, and/or safety/toxicology. 

About You

• MD, MD/PhD, or PhD with 4+ years of experience in in vivo studies focused on proof-of-concept, PK/PD, and/or safety/toxicology
• Experience with evaluating, prioritizing, and characterizing in vivo models 
• Experience with and knowledge of the process of therapeutic/drug evaluation from early to late phases of non-clinical development 
• Experience with and knowledge of working in standardized and protocolized environments (e.g. good lab practice, GLP)
• Experience evaluating, engaging, establishing, and partnering with contract research organizations (CROs) 

Nice to Have 

• Experience and knowledge of neurological and psychiatric disorders and in vivo animal models  with an emphasis on epileptic, neurodegenerative, and cognitive disorders
• Experience with investigational new drug (IND) submissions, particularly in auditing, approving study reports and preparing non-clinical summaries 
• Experience with evaluating, selecting, and qualifying/validating biomarkers 
• Experience with established or novel bioanalytical, molecular, or histological assays to inform in vivo studies
• Experience with early phase clinical trials to inform non-clinical strategy