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Principal Software Engineer - Helix

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Job Title
Principal Software Engineer
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Job Description

You + Helix

Helix is a place where innovators and doers gather in order to drive significant progress in population genomics. We have come together to work at the intersection of clinical care, research, and genomics.  

If you’re excited by the idea of making a meaningful impact and joining a team where we pride ourselves on driving innovation through fostering an environment with an emphasis on empowering one another to grow, Helix might be the place for you!

Helix + The World

Helix is the leading population genomics and viral surveillance company. Helix enables health systems, public health organizations and life science companies to accelerate the integration of genomic data into patient care and public health decision making.

We are continuing to scale our world-class team to support our dedication to empowering every person to improve their life through DNA. 


What is special about this role?

Lead large-scale architecture initiatives and build Platform services that broadly impact Helix Engineering and our partners.


As a Principal Software Engineer, you will:

  • Architect robust distributed systems designs that are highly secure and performant.

  • Code systems and components that support wide-ranging product lines at Helix, from genomics to viral surveillance, lab systems to diagnostics.

  • Innovate on healthcare data access patterns and interoperability in order to improve health equity.

  • Collaborate with product managers, bioinformaticians, and scientists to build platform services.

  • Establish strong engineering practices that are adopted across the organization.

  • Mentor other engineers to reinforce a culture of learning and teaching.


About you:

  • 10+ years development experience Go, Python, Java, Javascript, or a similar language

  • Expertise developing software on public cloud platforms — AWS, Azure, or GCP

  • Affinity for an engineering culture that emphasizes agile, DevOps, and continuous delivery

  • A proven track record of successful, large-scale projects



  • BS+ in Computer Science; coursework in genetics or bioinformatics

  • Familiarity with regulated software systems and entities

  • Familiarity with full-stack development


What’s important to us:

•Curiosity — we are all passionate about the possibilities enabled by having access to your own genome

•Responsibility — we have an obligation to people and our partners to operate with highly credible research guided by well respected advisors, with clear and effective communication about our products

•Agility — flexibility and a desire to be nimble, smart, and effective are important to the Helix culture

•Follow-through — we’re building a diverse team with amazing track records of achievement in multidisciplinary environments


What Helix has to offer you:

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

•Competitive compensation, Comprehensive Health insurance package including employer sponsored HSA 

•12 weeks of Maternity or Paternity leave

•401(k) with employer matching and 100% vested on first day

•Comprehensive Well Being benefits

•Flexible PTO

Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.


Helix Headquarters Location

San Mateo, CA

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Helix Company Size

Between 150 - 500 employees

Helix Founded Year


Helix Total Amount Raised


Helix Funding Rounds

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  • Series C

    $50,000,000 USD

  • Grant

    $33,000,000 USD

  • Series B

    $200,000,000 USD

  • Series Unknown

    $20,000,000 USD

  • Series A

    $100,000,000 USD

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Helix's Tech Stack

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