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Nonclinical Operations Specialist - Alltrna

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Job Title
Nonclinical Operations Specialist
Job Location
Cambridge, Massachusetts, United States
Job Description

About Alltrna

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit

About The Role 

Come join a creative and collaborative team of scientists dedicated to leveraging emerging insights in RNA biology to develop novel classes of oligonucleotide therapeutics to treat human diseases and improve human health. In this role you will play a critical role in DMPK Group and work closely with internal partners and external collaborators to enable identification of multiple drug candidates for human clinical studies. Please apply if you feel that you can contribute to growing our team and advance our mission. As an early member of a privately held, well-funded, early-stage platform biotechnology company, you will contribute to the platform development, drug discovery, and translation into the clinic along with opportunities for professional growth. You will also benefit from opportunities to engage with the broader Flagship Pioneering ecosystem.

We are seeking a Specialist, Nonclinical Operations to support a variety of the preclinical activities including bioanalytical, DMPK, and toxicology studies. The ideal candidate is a driven professional who knows how to contribute to multiple projects and activities in a nimble working environment and enjoys working in close collaboration with multiple functions in a small company environment. Principally, the position will interact with DMPK, Pharmacology, Discovery and other functions across the organization as well as external partners (e.g., CRO or academic organizations). This position will report to the Director, DMPK and is based in Cambridge, MA.

 Core Responsibilities

  • Manage and coordinate the scheduling of studies and technical resources with CRO partners; ensure timly coverage of internal needs.
  • Perform study monitor activities for nonclinical studies conducted at various CROs, working with the Study Director and the internal study lead.
  • Coordinate all aspects of outsourced nonclinical safety studies independently (e.g., assessing test material amounts requirements, determining availability, coordinating analytical testing and shipments/specimen shipment, protocol development, dose level selection presentations, data and report review on an on-going basis, and study archival).
  • Support Nonclinical and Discovery efforts across multiple functions and capacities, including but not limited to compiling meeting minutes, tracking action items, executing logistics, managing documents and databases, coordinating timelines and milestones, and supporting team decision-making
  • Proactively identify risks, gaps, and resource bottlenecks while developing and implementing mitigation plans
  • Facilitate cross-functional communication by building strong working relationships across and between platform R&D, drug discovery & drug development

Qualifications and Skills 

  • Qualified candidate should have at least a BS/BA with 2+ years or MS of experience in the biotech/pharmaceutical industry.
  • Demonstrated ability to coordinate study execution at external organizations and ensure timely communication between all stakeholders.
  • Experience in utilizing software tools for data management (sample inventory, tracking and chain of custody, document management, etc.).
  • Knowledge OR previous experience with general principles and methods of in vivo studies, animal welfare standards (USDA, AALAC, etc.), animal and human biology and physiology preferred.
  • Excellent verbal and written communication skills, interpersonal skills, strong organization skills and attention to details, ability to prioritize, and demonstrated ability to manage by influence and problem solve in a highly matrixed organization
  • Demonstrate the ability to work in a methodical and organized fashion; understand the material and documents workflow.
  • Basic experience working in a biochemistry-oriented wet lab is preferred, but not required.

What We’ll Offer You

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

Our Core Values


1. PATIENTS DESERVE BETTER. We are transforming medicine, boldly building a new future for patients.

2. CURIOSITY SPARKS DISCOVERY. We ardently explore the unknown, catalyzing new scientific breakthroughs.

3. COURAGE PROPELS US FORWARD. We take thoughtful risks without fear of failure, growing with each experience.

4. OUR PURPOSE FUELS US. We each lead and work with focus and passion to design groundbreaking tRNA medicines.

5. WE ARE ONE TEAM. We are united on trust and collaboration, embracing all voices and experiences.


Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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Alltrna Headquarters Location

Cambridge, MA

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Alltrna Company Size

Between 20 - 100 employees

Alltrna Founded Year


Alltrna Total Amount Raised


Alltrna Funding Rounds

View funding details
  • Series B

    $109,000,000 USD

  • Series Unknown

    $50,000,000 USD

Alltrna's Industries