Clinical Program Operations Manager, Therapeutics & Innovations - Natera

We are seeking a hands-on, execution-focused Clinical Program Operations Manager with deep experience in oncology and clinical trial operations to lead the day-to-day delivery and execution of our therapeutic clinical programs. This role is central to ensuring our studies move forward with precision, on schedule, within scope, and aligned with company goals. You will manage complex timelines, coordinate cross-functional efforts, and support external relationships critical to clinical delivery.

This is a high-impact opportunity for someone who thrives in a fast-moving environment. You’ll bring strong oncology trial experience, a solution-first mindset, and the ability to drive clarity and progress even when priorities shift.

This role is best suited for individuals who thrive in fast-paced, dynamic environments, take initiative, and are comfortable leading through ambiguity. We’re looking for someone sharp, solution-obsessed, and relentless about execution, someone who moves fast, thrives in ambiguity, and gets things done without excuses.

Key Responsibilities

Program Execution & Timeline Management

• Own, drive, and enforce comprehensive trial timelines, deliverables, and Gantt charts; ensure alignment across functions and hold teams accountable for execution.
• Identify risks early and fix them fast.
• Collaborate closely with internal functions (e.g., clinical operations, regulatory, quality, medical) and external CROs/vendors.
• Ensure real-time visibility of program status for leadership and cross-functional partners.

Operational Leadership

• Oversee study startup activities, including site selection, feasibility, and trial initiation.
• Manage CRO relationships and performance, including KPIs, deliverables, and contracts.
• Ensure operational readiness for investigator meetings, site visits, and data reviews, in collaboration with cross-functional teams.
• Dive into the weeds when necessary and eliminate roadblocks without being asked.

Stakeholder Engagement & Field Leadership

• Serve as the primary operational liaison for internal and external trial communications.
• Prepare structured updates, dashboards, and risk logs for senior leadership and the steering committee.
• Travel (up to ~25%) to clinical sites, CROs, investigator meetings, and key partners to ensure operational excellence, build relationships, and represent clinical leadership on the ground.
• Foster strong relationships with investigators and site personnel to ensure engagement and performance.

Scientific Contribution

• Attend data review meetings and contribute to clinical insight generation and action plans.
• Help translate scientific and clinical objectives into executable operational strategies and trial designs.

Qualifications

• Advanced degree (PhD, PharmD, MD, or MS) in a life science or clinical field is required.
• Minimum 5 years of experience in clinical research with a strong emphasis on program management and oncology trials.
• Proven ability to manage trial timelines and operations in a cross-functional, fast-moving environment.
• Acts fast, follows through relentlessly, and owns outcomes under pressure.
• Excellent communication, organizational, and leadership skills.
• Startup or small biotech experience strongly preferred.